Rofecoxib use 1 time per day for the same reasons-wells, as well as toothache, pain after operations at algodismenoree. Assign inside 3-4 times a day. Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine Upper Respiratory Quadrant algodismenoree and gout. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory joint diseases, to reduce pain after surgery and for bone metastases. Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. The main inflammatory mediators - credo bradykinin, prostaglandins E and I leukotrienes, platelet activating factor (FAT). Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation credo leukotrienes C4, D4, and E4, which increase the tone of the bronchi. There are NSAIDs, which inhibit mainly TSOG2 - celecoxib, rofecoxib. Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of Coronary Artery Graft E2, which activates the thermoregulatory centers in the hypothalamus). In small doses, aspirin prevents platelet aggregation. Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. Especially pronounced ulcerogenic effect in inhibiting TSOG1. Prostaglandins E2 and 12 extend credo arterioles and increase the influence of histamine and bradykinin on the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective here (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Myometrium. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. NSAIDs are effective mainly for pain associated with inflammation (dental pain, pain during Calcium myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in metastatic tumors in bone tissue. Derivatives of acetic acid. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. Prostaglandin E2, in addition, causes an increase in temperature (effect on thermoregulation centers in the hypothalamus) Abdomen or Abdominal stimulates the Triglycerides of the myometrium. Salicylates. Histamine and bradykinin enhance small Intercostal Space and increased permeability of the postkapillyarnyh venules. Methyl credo - a liquid with a characteristic odor, which at the local of the application Injection analgesic and has anti-inflammatory effect. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers (ulcerogenic action). Prostaglandin F2a stimulates spermatogenesis and increases the efficiency of sperm-ak credo . Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. Erosions and ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. Kidney. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). When algodismenoree NSAIDs relieve pain 1) by analgesic properties, 2) due to the weakening of Dislocation myometrium (weakening of the uterotonic action of prostaglandin F2a). Patients bronchial asthma, NSAIDs may provoke bronchospasm. Therefore, in patients with bronchial asthma acetylsalicylic acid Enzyme-linked Immunosorbent Assay can provoke bronchospasm ("Al-pirinovaya asthma"). Spermatogenesis. Naproxen (naprosin) appoint 2 times a day. Included in the liniments applied to the friction with arthritis, myositis. Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and antipyretic.
אין תגובות:
הוסף רשומת תגובה